We investigate mechanisms of neurodegeneration and conduct studies towards the development of therapeutics for neurodegenerative diseases.

We have been focusing our research primarily on the fatal polyglutamine disorder Machado-Joseph disease (MJD), also known as Spinocerebellar ataxia type 3 (SCA3).

Our lab is currently interested in:

  1. investigating mechanisms that regulate the abundance of the mutant ATXN3 gene and proteins in MJD/SCA3.
  2. developing therapeutic approaches for MJD/SCA3.
  3. understanding the function of native and mutant ATXN3 proteins.


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